重组III型人源化胶原蛋白,化妆品,Collagen III Protein, 有丰富的整合素识别位点,如GPAGEK、GAPGER和GPAGFR,可与成纤维细胞表面的受体相互作用,增强整合素的结合,并进一步调节细胞识别、黏附和迁移。同时,重组人源化III型胶原蛋白的柔性弯曲度,利于与细胞受体蛋白更好的结合。
胶原蛋白是人体内数量庞大,含量丰富的蛋白质,广泛分布于人体的组织,主要存在于皮肤、骨骼、肌肉、血管、内脏,软骨等部位,是重要的人体原材料,堪称为人体生命支架。
重组III型人源化胶原蛋白,功能区域具有164.88°;柔性弯曲三螺旋结构。
*Chen Hua a, Yun Zhu b, Wei Xu, et al. Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity. [J] Biochem Biophys Res Commun. 2019 Jan 22;508(4):1018-1023
重组III型人源化胶原蛋白功效
* Shuang You, Shuaibin Liu, Xiaojing Dong, et al. Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats. [J] ACS Biomater Sci Eng. 2020 Apr 13;6(4):1977-1988.
* Jing Wang, Hang Wang, Hai Lin, Xingdong Zhang, et al. The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging: An in vivo study.[J] Bioactive Materials. 2021
* Shuang You, Shuaibin Liu, Xiaojing Dong, et al. Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats. [J] ACS Biomater Sci Eng. 2020 Apr 13;6(4):1977-1988.
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